Treat-to-target achievement and predictive analysis in childhood-onset systemic lupus erythematosus
Authors' conclusion
This single-centre study demonstrates that cLLDAS and cCR are achievable targets in real-life clinical practice. However, maintaining stability in both states remains highly challenging.
Study context
- Population
- Untreated patients with childhood-onset SLE (cSLE), Wuhan Children's Hospitalmedian follow-up 2.6 years
- Participants
- 97 patients
- Outcome
- Achievement of treat-to-target (LLDAS, cLLDAS, DORIS remission, childhood-onset clinical remission)
Methodological detailsretrospective application to prospectively gathered data, real-world cohort, single-centre
- Retrospective application to prospectively gathered data
- Real-world cohort
- Single-centre
Main finding
As reported in the abstract
Achievement of treat-to-target (T2T) targets · median follow-up 2.6 years
- Lupus low disease activity state (LLDAS) achieved
- 75 (77.32%)
- cLLDAS achieved
- 70/97 (72.16%)
- Definitions of Remission in SLE (DORIS) achieved
- 64/90 (65.98%)
- cCR achieved
- 41/97 (42.27%)
- Median time to LLDAS (years)
- 1.22
- Median time to cLLDAS (years)
- 1.44
- Median time to DORIS (years)
- 1.49
- Median time to cCR (years)
- 1.52
Observational data: associations, not effects.
Further findings
Maintained state for over half of follow-up (−50)
- LLDAS-50
- 40.21%
- cLLDAS-50
- 30.93%
- DORIS-50
- 23.71%
- cCR-50
- 19.59%
Predictors of target achievement
- Male patients achieved cLLDAS and DORIS earlier
- Longer disease duration at initial diagnosis was a positive factor for achieving cLLDAS and cCR
- Glucocorticoid (GC) pulse therapy was a negative predictor for time to cLLDAS and DORIS
- Earlier first cLLDAS or cCR associated with higher probability of cLLDAS-50 and cCR-50
Original publication
Treat-to-target achievement and predictive analysis in childhood-onset systemic lupus erythematosus. Rheumatology (Oxford). Published 25 November 2025. doi:10.
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