Comparison of clinical practices during the transitional and young adult phases between patients with oligoarticular/polyarticular juvenile idiopathic arthritis and those with rheumatoid arthritis in Japan
Authors' conclusion
Despite an overlap in age, patients with JIA and RA exhibit distinct disease characteristics and therapeutic patterns.
Study context
- Population
- Patients aged 16–30 years with oligoarticular/polyarticular juvenile idiopathic arthritis (JIA) or rheumatoid arthritis (RA), nationwide multicentre databases in Japan
- Participants
- 176 vs 152
- Exposure
- Oligoarticular/polyarticular JIA vs RA, patients aged 16-30 years
- JIAn = 176
- RAn = 152reference
- Outcome
- Disease activity, medication use and treatment practices
Methodological detailstwo nationwide multicentre databases (NinJa, CoNinJa), Mann-Whitney U test and Fisher's exact test
- Two nationwide multicentre databases (NinJa, CoNinJa)
- Mann-Whitney U test and Fisher's exact test
Main finding
As reported in the abstract
Disease activity (SDAI), median
JIA
0.6
median
RA
2.4
median
Observational data: associations, not effects.
Further findings
Boolean remission
P < 0.001
MTX use
P < 0.001
Biologic use
P < 0.001
Biologic monotherapy among patients in CDAI remission
P < 0.001
- Biologic use — Off-label prescriptions
- 31%
Reasons for MTX discontinuation
- Disease improvement
- 58%
- GI intolerance (nausea)
- 29%
Discontinuation rate of subcutaneous tocilizumab (lowest)
- Subcutaneous tocilizumab discontinuation
- 4%
- Unapproved for JIA in Japan
Original publication
Comparison of clinical practices during the transitional and young adult phases between patients with oligoarticular/polyarticular juvenile idiopathic arthritis and those with rheumatoid arthritis in Japan. Pediatr Rheumatol Online J. Published 24 November 2025. doi:10.
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