Vaccination coverage, immune responses, and clinical characteristics in children with PFAPA syndrome: a monocentric prospective study
Authors' conclusion
Children with PFAPA demonstrate high adherence to vaccination schedules and adequate immune responses, supporting the safety and effectiveness of routine immunization in this group.
Study context
- Population
- Children with PFAPA syndrome followed at Geneva University Hospitals, February 2022–April 2025
- Participants
- 41 children
- Outcome
- Vaccination coverage and serological responses
Methodological detailsmonocentric
- Monocentric
Main finding
As reported in the abstract
Primary DTaP-IPV-Hib-HBV series received on time
90-95%
MenC/MenACWY vaccination on time
58%
Protective pneumococcal titers
40%
Varicella immunity from past infection (none vaccinated)
65%
Observational data: associations, not effects.
Further findings
Clinical and genetic characteristics
- All had elevated inflammatory markers during febrile episodes
- No monogenic cause identified
Original publication
Vaccination coverage, immune responses, and clinical characteristics in children with PFAPA syndrome: a monocentric prospective study. Pediatr Rheumatol Online J. Published 24 November 2025. doi:10.
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