Presence and reactivities of antibodies directed to citrullinated peptides in a Swedish JIA cohort
Authors' conclusion
This study reveals a distinct pattern of antibody reactivity to citrullinated peptides in a subset of patients with juvenile idiopathic arthritis, suggesting a biologically distinct subgroup with similarities to adult rheumatoid arthritis.
Study context
- Population
- Swedish cohort of patients with JIA100 profiled by microarray
- Participants
- 334 participants
- Exposure
- Positive for cyclic citrullinated peptide antibodies vs antibody-negative
- Outcome
- Antibodies against cyclic citrullinated peptides (ELISA)
Methodological detailsELISA for anti-CCP, multiplex microarray profiling in a subset of 100 patients
- ELISA for anti-CCP
- Multiplex microarray profiling in a subset of 100 patients
Main finding
As reported in the abstract
Anti-CCP prevalence
Anti-CCP detected
6.2%
Observational data: associations, not effects.
Further findings
Reactivity to ≥1 citrullinated peptide (microarray, 100 profiled)
Reactivity to ≥1 citrullinated peptide (microarray, 100 profiled)
- Most frequent reactivities against filaggrin, fibrinogen, vimentin and enolase peptides
- Reactivity to non-citrullinated peptides minimal
- Significant association between citrullinated vimentin reactivity and HLA-DRB1 shared epitope alleles
Original publication
Presence and reactivities of antibodies directed to citrullinated peptides in a Swedish JIA cohort. Pediatr Rheumatol Online J. Published 22 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →