Adverse childhood experiences are associated with disease and mental health outcomes in childhood-onset SLE
Authors' conclusion
ACEs exposure was prevalent in this cSLE cohort, associated with NPSLE diagnosis, disease damage and comorbid psychiatric diagnoses.
Study context
- Population
- cSLE outpatients aged 9–18 years at a Canadian tertiary centre, July 2018 to June 202041% had documented adverse childhood experiences (ACEs)
- Participants
- 224 outpatients
- Exposure
- ACEs vs no ACEs
- Outcome
- Disease activity, disease damage and comorbid psychiatric diagnoses (not attributable to cSLE)
Methodological detailssingle-centre, regression models adjusted for sex, ethnicity, age at diagnosis, disease duration, nephritis/neuropsychiatric SLE (NPSLE) and GC use
- Single-centre
- Regression models adjusted for sex, ethnicity, age at diagnosis, disease duration, nephritis/NPSLE and GC use
Main finding
As reported in the abstract
Each group vs no ACEsAdjusted odds ratio (95% CI)P value
ACEs before diagnosisdisease damage
3.10(1.21–8.04)
P = 0.018ACEs after diagnosiscomorbid psychiatric diagnosis
5.01(1.20–21.12)
P = 0.025Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| NPSLEACEsvs No ACEs | 3.40 (1.55–7.78) | P = 0.003 | |
| NPSLEACEs before diagnosisvs No ACEs | 2.67 (1.02–6.98) | P = 0.043 | |
| 0.10.31310Adjusted odds ratio (log scale) |
LN and arthritis
- ACEs were not associated with nephritis or arthritis
Original publication
Adverse childhood experiences are associated with disease and mental health outcomes in childhood-onset SLE. Lupus Sci Med. Published 20 April 2026. doi:10.
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