Defining pain trajectories in juvenile arthritis and associated patient characteristics
Authors' conclusion
We identified three latent pain trajectories differentiating JIA patients' pain course as mild resolving, moderate slowly resolving, or moderate chronic. Older age was significantly associated with moderate and chronic trajectories.
Study context
- Population
- Patients with juvenile idiopathic arthritis (JIA), data from Electronic Health Records (EHR) with follow-up every three monthsplasma samples of 24
- Participants
- 233 patients
- Exposure
- Latent pain trajectories (mild, moderate, chronic) compared for clinical and biological characteristics
- Outcome
- Latent pain trajectories of pain scores and their association with clinical and biological patient characteristics
Methodological detailslatent trajectory modelling, exploratory plasma proteomics subset
- Latent trajectory modelling
- Exploratory plasma proteomics subset
Main finding
As reported in the abstract
Latent pain trajectories
- Model with three distinct trajectories most representative: mild resolving, moderate slowly resolving, moderate chronic
- 3
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Baseline Patient/Parent Global Assessment (PPGA)Mild vs Moderate and Chronic · PPGA significantly lower in mild trajectory | P < 0.001 |
Baseline disease activity (Active Joint Count (AJC) and Physician Global Assessment (PhGA)) between trajectories
- AJC did not significantly differ between trajectories
- P = 0.4
- PhGA did not significantly differ between trajectories
- P = 0.6
Plasma proteins differing between trajectories (exploratory, 24 patients)
- Proteins differing at baseline (Aβ-40, GFAP, IGFBP7, IL-12p70, IL-2, IL-5, NPY, TREM2, UBB)
- 9
- Proteins differing at follow-up (IL-4, pTau-217, IGF1R, IL-6, pTau-231, SNAP25, CXCL8, GOT1, CCL2, BACE1, CST3)
- 11
- No overlap between protein sets at baseline and follow-up
- Exploratory analysis
Original publication
Defining pain trajectories in juvenile arthritis and associated patient characteristics. Arthritis Res Ther. Published 18 April 2026. doi:10.
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