Pediatric rheumatology

Systematic Literature Review Informing Paediatric Rheumatology European Society/Childhood Arthritis and Rheumatology Research Alliance–Endorsed Recommendations for the Treat-to-Target Strategy in Juvenile Dermatomyositis

J RheumatolPublished Systematic literature review

Authors' conclusion

This SLR provides a comprehensive overview of the current knowledge that served as the basis for the consensus definition of the overarching principles and recommendations for the T2T strategy in JDM.

Study context

Population
Published studies on the treat-to-target (T2T) strategy in juvenile dermatomyositis (JDM) (clinical trials, observational studies, case reports of > 2 patients, expert recommendations, systematic reviews) until March 2023220 articles included
Outcome
Evidence on T2T strategy in JDM
Methodological detailsGrading of Recommendations, Assessment, Development, and Evaluation (GRADE) quality assessment (modified), 14 research questions formulated by the steering committee, MEDLINE, Embase, Cochrane Central and Web of Science searched
  • GRADE quality assessment (modified)
  • 14 research questions formulated by the steering committee
  • MEDLINE, Embase, Cochrane Central and Web of Science searched

Main finding

As reported in the abstract

Articles retrieved from databases

2714

Articles included in final review

220

Articles with strong evidence

2

Articles with moderate evidence

22

Original publication

Systematic Literature Review Informing Paediatric Rheumatology European Society/Childhood Arthritis and Rheumatology Research Alliance–Endorsed Recommendations for the Treat-to-Target Strategy in Juvenile Dermatomyositis. J Rheumatol. Published 15 April 2026. doi:10.3899/jrheum.2025-1157

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