Towards development of treat to target (treat-to-target (T2T)) in childhood-onset systemic lupus erythematosus: PReS-endorsed overarching principles and points-to-consider from an international task force
Methodological detailsoverarching principles and points-to-consider, systematic literature review, Delphi surveys, modified nominal group technique, consensus >80% agreement
- Overarching principles and points-to-consider
- Systematic literature review
- Delphi surveys
- Modified nominal group technique
- Consensus >80% agreement
Recommendations
As issued by the authors
Treatment targets and therapeutic strategies should be subject to shared decision making with the patient/caregivers
Full remission is the preferred target; low disease activity acceptable where remission cannot be achieved
Aim for prevention of flare and organ damage
GC sparing
Proactively address factors impacting health-related quality of life (fatigue, pain, mental health, educational challenges, medication side effects)
Aim for maintenance of the target over the long-term
Original publication
Towards development of treat to target (T2T) in childhood-onset systemic lupus erythematosus: PReS-endorsed overarching principles and points-to-consider from an international task force. Ann Rheum Dis. Published 10 January 2023. doi:10.
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