Serological response after COVID-19 infection compared to vaccination against COVID-19 in children with autoimmune rheumatic diseases
Authors' conclusion
IgG and IgA anti-SARS-CoV-2 levels were higher after vaccination and after both events compared to after infection only.
Study context
- Population
- Paediatric patients with autoimmune rheumatic diseases (pARD), data collected March 2020 to April 2022
- Exposure
- SARS-CoV-2 infection vs vaccination with two doses of BNT162b2 vs both events in pARD
- After infectionn = 92reference
- After vaccinationn = 47
- After both eventsn = 24
- Outcome
- Serological response compared between 3 groups of pARD: after SARS-CoV-2 infection, after vaccination (2 doses BNT162b2) and after both events
Main finding
As reported in the abstract
Serological response (anti-SARS-CoV-2 IgG and IgA levels)
- Serological response better after vaccination and after both events compared to after infection only
- No effect of medication on antibody levels
- Serological data available for 47 after infection, 25 after vaccination, 21 after both events
Observational data: associations, not effects.
Further findings
No symptomatic COVID-19 infection in vaccinated pARD · observation period of 41.3 weeks
- Vaccinated pARD who did not experience a symptomatic COVID-19 infection
- 60%
Safety
Systemic adverse events (AE) after first vaccine dose
- More common in healthy adolescents compared to pARD; safety profile of the vaccine was good
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Serological response after COVID-19 infection compared to vaccination against COVID-19 in children with autoimmune rheumatic diseases. Pediatr Rheumatol Online J. Published 25 July 2024. doi:10.
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