Childhood-onset systemic lupus erythematosus: A descriptive and comparative study of clinical, laboratory, and treatment characteristics in two populations
Authors' conclusion
Our findings suggest an earlier age of disease onset and a higher prevalence of kidney involvement in Turkish patients. Differences in treatment approaches were also noted. However, damage accrual related to SLE does not appear to be different between the two patient populations.
Study context
- Population
- Patients with childhood-onset systemic lupus erythematosus (SLE) fulfilling the 1997 ACR classification criteria, Turkey and the United States
- Participants
- 174 patients
- Exposure
- Turkish vs U.S. childhood-onset SLE cohorts
- Turkeyn = 108
- U.S.n = 66
- Outcome
- Age at diagnosis
Methodological detailsmulticentre, descriptive and comparative
- Multicentre
- Descriptive and comparative
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | U.S. | P value |
|---|---|---|
| PhotosensitivityTurkish cohort vs U.S. cohort | 21.2% | P = 0.007 |
| Renal involvementTurkish cohort vs U.S. cohort | 36.4% | P = 0.045 |
| Anti-Ro/SSA positivityU.S. cohort vs Turkish cohort | 34.8% | P < 0.001 |
| Anti-Sm positivityU.S. cohort vs Turkish cohort | 59.1% | P < 0.001 |
| Anti-RNP positivityU.S. cohort vs Turkish cohort | 47.0% | P < 0.001 |
| Current RTX useU.S. cohort vs Turkish cohort | 37.9% | P < 0.001 |
| Current belimumab useU.S. cohort vs Turkish cohort | 19.7% | P < 0.001 |
| CYC use throughout disease course (often low-dose Euro-Lupus protocol)Turkish cohort vs U.S. cohort | 4.5% | P < 0.001 |
- Female-to-male ratio · Turkish cohort vs U.S. cohort
- P = 0.73
- Photosensitivity: Turkish cohort 45.4%
- Renal involvement: Turkish cohort 41.7%
- Anti-Ro/SSA positivity: Turkish cohort 15.7%
- Anti-Sm positivity: Turkish cohort 19.4%
- Anti-RNP positivity: Turkish cohort 14.8%
- Current RTX use: Turkish cohort 1.9%
- Current belimumab use: Turkish cohort 0%
- CYC use throughout disease course (often low-dose Euro-Lupus protocol): Turkish cohort 24.1%
Female-to-male ratio
- Similar between the two cohorts (∼3:1)
SLICC/ACR DI scores
- Not different between the two cohorts
Original publication
Childhood-onset systemic lupus erythematosus: A descriptive and comparative study of clinical, laboratory, and treatment characteristics in two populations. Lupus. Published 22 July 2024. doi:10.
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