Clinical characteristics and prognostic factor in juvenile dermatomyositis: data of the Spanish registry
Main findingResult — go to the resultHazard ratio per month of evolution 0.95Authors' conclusion
We describe heliotrope rash as a risk factor for developing complications in our cohort of JDM patients
Study context
- Population
- Juvenile Dermatomyositis (JDM) patients included in the Spanish JDM registry, 17 Spanish paediatric rheumatology centres76 girls (65%)
- Participants
- 116 patients
- Outcome
- Epidemiological, clinical and laboratory characteristics at diagnosis; prognostic factors for complications and time to disease inactivity
Methodological detailsregistry-based, multicentre, retrospective review
- Registry-based
- Multicentre
- Retrospective review
Main finding
As reported in the abstract
Hazard ratio per month of evolution
0.95
P = 0.02
- Girls
- 76 (65%)
- Median age at diagnosis, years (IQR)
- 7.3 (4.5-10.2)
- Pathognomonic skin lesions at onset
- All patients
- Muscle weakness
- 86.2%
- Median Childhood Muscle Assessment Scale (IQR)
- 34 (22-47)
- Dysphagia
- 12 (34%)
- Calcinosis
- 29
- Macrophage activation syndrome
- 4
- Reached inactivity; median time, months (IQR)
- 70%; 8.9 (4.5-34.8)
- Relapsed after inactivity; median time, months (IQR)
- 41%; 14.4 (8.6-22.8)
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value |
|---|---|---|
| Prognostic factorsShorter time to treatment associated with better prognosis | 0.95 | P = 0.02 |
Prognostic factors
- Heliotrope rash at diagnosis correlates with higher risk of developing complications
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Clinical characteristics and prognostic factor in juvenile dermatomyositis: data of the Spanish registry. Pediatr Rheumatol Online J. Published 22 July 2024. doi:10.
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