Long-term outcomes of childhood-onset systemic lupus erythematosus
Authors' conclusion
The prevalence of damage remains high in patients with cSLE even when the diagnosis of cSLE has been made in the recent decades.
Study context
- Population
- Patients with childhood-onset SLE (cSLE) diagnosed between 1971 and 2015median follow-up 15.4 [9.6–22.4] years
- Participants
- 138 patients
- Outcome
- Long-term outcomes: damage (SLICC/ACR DI ≥1) and persistent disease activity (SLEDAI ≥6)
- Follow-up
- Last
Methodological detailsmulticentre, registry-based (PEDIALUP registry, Juvenile Inflammatory Rheumatism (JIR) cohort database), multivariate analysis
- Multicentre
- Registry-based (PEDIALUP registry, JIR cohort database)
- Multivariate analysis
Main finding
As reported in the abstract
Damage (SLICC-DI ≥1) at last follow-up
- Patients with SLICC-DI ≥1; most common: musculoskeletal, cutaneous, renal, neurological and cardiovascular damage
- 51%
- Proportion with SLICC-DI ≥1 increased significantly with duration of follow-up
- P < 0.001
- Duration of follow-up associated with cumulative damage (multivariate), OR 1.08, 95% CI 1.01, 1.15
- P = 0.035
- Active disease (SLEDAI ≥6) at last visit
- 34%
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Active disease at last visit, sub-Saharan Africanvs Caucasian ethnicityMultivariate analysis | 7.44 (2.24–24.74) | P = 0.0002 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Long-term outcomes of childhood-onset systemic lupus erythematosus. Rheumatology (Oxford). Published 15 July 2024. doi:10.
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