Prepubertal to adolescent lupus: Age-related variations in clinical, laboratory, and outcome profiles
Authors' conclusion
This review underscores both similarities and differences in cSLE across age groups. Prepubertal onset was associated with higher mortality
Study context
- Population
- Childhood-onset SLE (cSLE) diagnosed before 18 years of age; English-language studies published January 2000–February 2025
- Participants
- 3,920 participants13 studies
- Comparison
- Prepubertal vs peripubertal vs adolescent-onset childhood-onset SLE
- Prepubertaln = 464
- Peripubertaln = 1,943
- Adolescent-onsetn = 1,513
- Outcome
- Age-related variations in cSLE
Methodological detailsPRISMA, NHLBI quality assessment, Searched PubMed, Cochrane Library and Web of Science; four reviewers screened independently, discrepancies resolved by a fifth
- PRISMA
- NHLBI quality assessment
- Searched PubMed, Cochrane Library and Web of Science; four reviewers screened independently, discrepancies resolved by a fifth
Pooled result
As reported in the abstract
| Group | Value | Mean age at diagnosis |
|---|---|---|
| Prepubertal | 11.8% | 5.8 ± 2.3 years |
| Peripubertal | 49.6% | 9.4 ± 2.5 years |
| Adolescent-onset | 38.6% | 13.9 ± 1.1 years |
Value
Prepubertal11.8%
Peripubertal49.6%
Adolescent-onset38.6%
Mean age at diagnosis
Prepubertal5.8 ± 2.3 years
Peripubertal9.4 ± 2.5 years
Adolescent-onset13.9 ± 1.1 years
- Female-to-male ratio highest in the adolescent-onset group
- P = 0.002
Further pooled results
| Outcome | Prepubertal | Adolescent-onset | P value |
|---|---|---|---|
| Lymphopenia | — not stated in the abstract | 60% | |
| MortalityPrepubertal vs Adolescent-onset | 16.5% | 2.9% | P = 0.014 |
— not stated in the abstract
- Lymphopenia — Lymphopenia more frequent in the adolescent-onset group (60% vs 25.6%)
- p = .016
Original publication
Prepubertal to adolescent lupus: Age-related variations in clinical, laboratory, and outcome profiles. Lupus. Published 11 July 2025. doi:10.
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