Age-related differences in clinical and laboratory characteristics of childhood-onset systemic lupus erythematosus: Pre-puberal-onset SLE is prone to delayed diagnosis
Authors' conclusion
The proportion of renal involvement and leukopenia in the pre-pubertal group was lower than that of the pubertal group and adolescent group. More importantly, the younger the age of the patient, the more likely the diagnosis to be delayed.
Study context
- Population
- Children with cSLE diagnosed at Beijing Children's Hospital, China, 2013–2021675 females and 178 males
- Participants
- 160 / 635 / 58
- Exposure
- Pre-pubertal vs peri-pubertal vs adolescent onset of childhood-onset SLE
- Pre-pubertaln = 160reference
- Peri-pubertaln = 635
- Adolescencen = 58
- Outcome
- Time from onset to diagnosis
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
P = <.0001
Observational data: associations, not effects.
Further findings
LN — Peri-pubertal and Adolescence vs Pre-pubertal · higher in peri-pubertal and adolescence
P = 0.044
Leukopenia
| Outcome | Pre-pubertal | Peri-pubertal | Adolescence |
|---|---|---|---|
| Female-to-male ratio | 3.5: 1 | 3.6: 1 | 7.28:1 |
Original publication
Age-related differences in clinical and laboratory characteristics of childhood-onset systemic lupus erythematosus: Pre-puberal-onset SLE is prone to delayed diagnosis. Lupus. Published 31 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →