Phenotype and disease course differences in monogenic and sporadic childhood lupus
Authors' conclusion
Patients with monogenic lupus are likely to have an early disease onset and a strong family history of lupus, as well as a guarded prognosis, which is likely due to the disease's severity and frequent infections.
Study context
- Population
- Children with lupus seen at a single tertiary childhood lupus clinic between June 1997 and July 2022
- Participants
- 54 children
- Exposure
- Monogenic lupus vs sporadic childhood lupus
- Monogenic lupusn = 27
- Sporadic childhood lupus (SC-lupus)n = 27reference
- Outcome
- Age at disease onset (years), monogenic vs sporadic childhood lupus
Methodological detailsdescriptive, observational, retrospective data collection, single tertiary centre, systematic sampling of SC-lupus
- Descriptive
- Observational
- Retrospective data collection
- Single tertiary centre
- Systematic sampling of SC-lupus
Main finding
As reported in the abstract
Monogenic lupus
3.5
median · IQR 1.0–6.0
SC-lupus
9.5
median · IQR 7.0–11.8
P < 0.05
Observational data: associations, not effects.
Original publication
Phenotype and disease course differences in monogenic and sporadic childhood lupus. Lupus. Published 25 October 2023. doi:10.
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