Adolescent and caregiver preferences for juvenile idiopathic arthritis treatment: a discrete-choice experiment
Authors' conclusion
Improved symptom control, prolonged time to next flare-up, and avoidance of adverse events such as headache, stomachache, nausea, and vomiting are desirable characteristics of treatment regimens for adolescents with JIA and their caregivers.
Study context
- Population
- Adolescents with juvenile idiopathic arthritis (JIA) and caregivers of children with JIA, United States (US) and United Kingdom (UK)
- Participants
- 197 / 100 / 207 / 200
- Comparison
- Hypothetical JIA treatment profiles varying in efficacy, side effects, mode and frequency of administration, and need for combination therapy
- US adolescentsn = 197
- UK adolescentsn = 100
- US caregiversn = 207
- UK caregiversn = 200
- Outcome
- Preference weights for treatment attributes and their conditional relative importance
Methodological detailsrandom-parameters logit model
- Random-parameters logit model
Main finding
As reported in the abstract
Treatment preferences
- On average, respondents preferred greater symptom control, greater time until next flare-up, less stomachache, nausea and vomiting, and fewer headaches
- US adolescents and caregivers generally indifferent across modes and frequencies of administration
- UK adolescents and caregivers preferred tablets, syrup or injections to IV infusions
- US and UK adolescents indifferent between monotherapy and combination therapy; UK caregivers preferred combination therapy to monotherapy
Further findings
Subgroup analysis
- Preference heterogeneity across characteristics incl. gender, treatment experience and symptom experience in adolescents and caregivers
Original publication
Adolescent and caregiver preferences for juvenile idiopathic arthritis treatment: a discrete-choice experiment. Pediatr Rheumatol Online J. Published 21 October 2023. doi:10.
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