Circulating prolactin level in Juvenile Systemic Lupus Erythematosus and its correlation with disease activity: a case control study
Authors' conclusion
A relationship between serum prolactin levels and juvenile SLE disease was detected. Neurological manifestations were more prevalent among SLE patients with hyperprolactinemia.
Study context
- Population
- Children with systemic lupus erythematosus (SLE) (juvenile SLE) and age- and sex-matched controls
- Participants
- 40 vs 40
- Comparison
- Children with SLE vs age- and sex-matched controls
- SLEn = 40
- Controlsn = 40reference
- Outcome
- Serum prolactin level (ELISA)
Methodological detailsage- and sex-matched controls
- Age- and sex-matched controls
Main finding
As reported in the abstract
Serum prolactin level
P = 0.005
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| Serum PRL by SLEDAI disease activity (mild, moderate, severe)Severe vs Mild · not statistically significant | Severe mean 19.3 (SD 7.7) µg/L · Moderate mean 17.0 (SD 5.3) µg/L · Mild mean 14.0 (SD 6.2) µg/L | P = 0.212 |
| Neurological manifestations, hyperprolactinemia vs normal PRL (SLE patients) | Hyperprolactinemia 50% · Normal PRL 9.4% | P = 0.007 |
Correlation of prolactin (PRL) with SLEDAI score
- Significant positive correlation, r
- 0.368
- P value
- 0.019
Hyperprolactinemia
- Hyperprolactinemia in SLE patients
- 8 patients (20%)
- Hyperprolactinemia in controls: not found
Original publication
Circulating prolactin level in Juvenile Systemic Lupus Erythematosus and its correlation with disease activity: a case control study. Pediatr Rheumatol Online J. Published 20 October 2023. doi:10.
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