Translation and validation in Italian of the methotrexate intolerance severity score for children and adults with arthritis
Authors' conclusion
We developed the Italian version of the MISS and showed its validity and reliability to identify patients intolerant to MTX in clinical practice and in a research setting.
Study context
- Population
- Patients with Juvenile Idiopathic Arthritis (JIA) followed at the Rheumatology Unit of Bambino Gesù Children Hospital
- Participants
- 125 patients
- Outcome
- Reliability, validity and diagnostic performance of the Italian MISS
Methodological detailstranslation and cross-cultural adaptation, single-centre
- Translation and cross-cultural adaptation
- Single-centre
Performance
As reported in the abstract
| Test or model | Cronbach α | Composite reliability | Cohen's κ | AUC | Sensitivity (threshold 6) | Specificity (threshold 6) |
|---|---|---|---|---|---|---|
| Italian MTX intolerance severity score (MISS) | 0.87 (95% CI, 0.84-0.90) | 0.89 (95% CI, 0.83-0.91) | 0.81 (95% CI, 0.71-0.91) | 0.97 (95% CI, 0.93-0.99) | 98.3% | 81.2% |
Italian MTX intolerance severity score (MISS)
Cronbach α0.87 (95% CI, 0.84-0.90)
Composite reliability0.89 (95% CI, 0.83-0.91)
Cohen's κ0.81 (95% CI, 0.71-0.91)
AUC0.97 (95% CI, 0.93-0.99)
Sensitivity (threshold 6)98.3%
Specificity (threshold 6)81.2%
Original publication
Translation and validation in Italian of the methotrexate intolerance severity score for children and adults with arthritis. Clin Exp Rheumatol. Published 19 October 2023. doi:10.
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