Potential involvement of circulating exosomal miRNA-146a in disease activity and TRAF6 gene expression in juvenile proliferative lupus nephritis
Authors' conclusion
This suggests that miRNA-146a might serve as a non-invasive biomarker to evaluate the response to treatment in patients with juvenile lupus nephritis.
Study context
- Population
- Children and adolescents with juvenile proliferative LN (Juvenile SLE (JSLE))
- Participants
- 12 children
- Exposure
- Circulating exosomal miRNA-146a over time (12 months vs diagnosis) and its correlation with TRAF6 mRNA and disease activity
- Outcome
- Circulating exosomal miRNA-146a: change over 12 months and correlation with TRAF6 mRNA
- Follow-up
- 12 months
Methodological detailslongitudinal sampling every 3 months for 1 year, Blood samples every 3 months until 1 year; quantitative real-time PCR for exosomal miRNA-146a and IRAK1/TRAF6 expression; mean age 12.60±0.43 years at diagnosis
- Longitudinal sampling every 3 months for 1 year
- Blood samples every 3 months until 1 year; quantitative real-time PCR for exosomal miRNA-146a and IRAK1/TRAF6 expression; mean age 12.60±0.43 years at diagnosis
Main finding
As reported in the abstract
- Circulating exosomal miRNA-146a significantly higher at 12 months than at diagnosis
- p<0.001
- Negative correlation between circulating exosomal miRNA-146a and TRAF6 mRNA
- r=−0.30, p=0.049
Observational data: associations, not effects.
Further findings
- All patients had a complete response at 12 months
Original publication
Potential involvement of circulating exosomal miRNA-146a in disease activity and TRAF6 gene expression in juvenile proliferative lupus nephritis. Lupus Sci Med. Published 14 February 2024. doi:10.
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