Adolescent Health Care Needs and Relationship to Disease in Patients With Childhood‐Onset Systemic Lupus Erythematosus
Authors' conclusion
Adolescents with cSLE experience many adolescent issues, especially low mood. High-dose glucocorticoids and social marginalization are associated with greater adolescent health burden.
Study context
- Population
- Adolescents aged 12 to 18 years with cSLE (ACR/SLICC criteria) seen by adolescent medicine in the cSLE clinic, Hospital for Sick Children, 2018–2020of 181 adolescents with cSLE
- Participants
- 108 adolescents
- Outcome
- Adolescent health issues (HEADDSS framework); adolescent health burden = number of distinct adolescent issues per patient
Methodological detailssingle-centre, multiple Poisson regression
- Single-centre
- Multiple Poisson regression
Main finding
As reported in the abstract
Adolescent health issues per patient · study period
- Adolescent health issues per patient, median (IQR 1-5)
- 2
- Adolescent medicine visits, median (IQR 1-3)
- 2
- Mood: presenting vs identified
- 21% vs 50%
- Sleep: presenting vs identified
- 27% vs 2%
- School and education: presenting vs identified
- 26% vs 1%
- Nonadherence: presenting vs identified
- 23% vs 8%
Observational data: associations, not effects.
Further findings
Factors associated with higher adolescent health burden (multiple Poisson regression)
| RR (95% CI) | P value | ||
|---|---|---|---|
| High-dose GC | 1.82 (1.41–2.35) | P < 0.001 | |
| Material deprivation | 1.17 (1.04–1.30) | P = 0.007 | |
| Lower SLE Disease Activity Index scoresAssociated with higher adolescent health burden | 0.95 (0.92–0.98) | P = 0.004 | |
| 0.512Relative risk (log scale) |
Original publication
Adolescent Health Care Needs and Relationship to Disease in Patients With Childhood‐Onset Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). Published 12 February 2024. doi:10.
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