Impact of follow-up adherence on disease activity in childhood-onset systemic lupus erythematosus (cSLE)
Authors' conclusion
Our findings suggest that cSLE patients with higher disease activity are at risk for increased health care utilization with respect to ED visits as well as hospitalizations in the setting of follow-up nonadherence.
Study context
- Population
- Children <18 years at diagnosis with systemic lupus erythematosus (SLE) meeting Systemic Lupus International Collaborative Clinics (SLICC) criteria, not seen in clinic within the previous 120 days
- Participants
- 41 children
- Exposure
- Lower vs higher disease activity
- Outcome
- Disease activity (SLEDAI) at last clinic visit in relation to follow-up adherence
Methodological detailsretrospective chart review
- Retrospective chart review
Main finding
As reported in the abstract
Factors associated with higher SLEDAI scores
- Time to follow-up associated with higher SLE disease activity index (SLEDAI) scores
- p < 0.001
- Hospitalizations associated with higher SLEDAI scores
- p = 0.017
- ED visits associated with higher SLEDAI scores
- p < 0.001
- Current high-dose prednisone associated with higher SLEDAI scores
- p = 0.019
Observational data: associations, not effects.
Original publication
Impact of follow-up adherence on disease activity in childhood-onset systemic lupus erythematosus (cSLE). Lupus. Published 26 April 2023. doi:10.
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