Predictors of damage accrual in childhood-onset SLE: a retrospective analysis from a tertiary lupus centre in Türkiye
Authors' conclusion
Our study confirms that higher median disease activity over time, haemolytic anaemia and renal disease are significant predictors of long-term damage in cSLE.
Study context
- Population
- Patients meeting SLICC 2012 criteria for childhood-onset SLE (cSLE), followed by a paediatric rheumatology clinic, 2004 to March 2023, tertiary lupus centre in Türkiye102 analysed
- Participants
- 120 patients
- Outcome
- Damage accrual (PedSDI≥1) and its risk factors
- Follow-up
- End of the study
Methodological detailssingle-centre, univariate and multivariate analyses, 18 excluded for monogenic lupus or inadequate follow-up, Mean age at diagnosis 12.9 years; mean disease duration 6.3 years
- Single-centre
- Univariate and multivariate analyses
- 18 excluded for monogenic lupus or inadequate follow-up
- Mean age at diagnosis 12.9 years; mean disease duration 6.3 years
Main finding
As reported in the abstract
Accrued damage (PedSDI≥1)
Patients with accrued damage (PedSDI≥1)
33.3%
Observational data: associations, not effects.
Further findings
Most frequently involved PedSDI domains
- Growth failure
- 24%
- Renal
- 11.8%
- Neuropsychiatric
- 8.8%
- Mucocutaneous
- 5.9%
Original publication
Predictors of damage accrual in childhood-onset SLE: a retrospective analysis from a tertiary lupus centre in Türkiye. Lupus Sci Med. Published 3 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →