Clinical correlates and predictors of thrombocytopenia in childhood-onset systemic lupus erythematosus: a retrospective cohort study
Authors' conclusion
Thrombocytopenia frequently occurs in pediatric patients with SLE and demonstrates a significant correlation with leukopenia, the presence of antiphospholipid antibodies, and involvement of major organs.
Study context
- Population
- Paediatric patients with Systemic Lupus Erythematosus (SLE), Children's Hospital of Fudan University, January 2020 to December 2025single-centre
- Participants
- 236 patients
- Exposure
- Thrombocytopenia vs no thrombocytopenia at SLE diagnosis
- Outcome
- Thrombocytopenia at SLE diagnosis and its clinical correlates and risk factors
- Follow-up
- At diagnosis
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Prevalence of thrombocytopenia
Thrombocytopenia
19.5%
46 events
Observational data: associations, not effects.
Further findings
Features associated with thrombocytopenia vs without
- Significantly increased incidences of leukopenia, leukocyte reduction, and positivity for aPL IgM, anti-β2-glycoprotein-1 antibody and LA in thrombocytopenia group
- P < 0.05
LA positivity, severe (platelets <50 × 10⁹/L) vs mild-to-moderate thrombocytopenia (subgroup)
- Severe thrombocytopenia correlated with markedly higher prevalence of LA positivity
Factors associated with thrombocytopenia (logistic regression)
- Leukopenia, elevated erythrocyte sedimentation rate (ESR), anti-β2 glycoprotein 1 antibody positivity, high LA and neuropsychiatric manifestations significantly associated with thrombocytopenia
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Clinical correlates and predictors of thrombocytopenia in childhood-onset systemic lupus erythematosus: a retrospective cohort study. Pediatr Rheumatol Online J. Published 6 June 2026. doi:10.
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