Clinical and laboratory predictors of diagnostic delay in childhood Takayasu arteritis and PAN: a retrospective cohort study
Authors' conclusion
Systemic symptoms such as fever and fatigue may obscure early recognition of vasculitis in children.
Study context
- Population
- Children diagnosed with Takayasu arteritis (TA) or childhood PAN (cPAN) at a single tertiary paediatric rheumatology centre, 2010–202567.4% female
- Participants
- 46 children
- Outcome
- Clinical, demographic and laboratory predictors of diagnostic delay; characteristics associated with delay >30 days
Methodological detailssingle-centre, tertiary paediatric rheumatology centre
- Single-centre
- Tertiary paediatric rheumatology centre
Main finding
As reported in the abstract
Diagnostic delay
- Median diagnostic delay (weeks)
- 13
- Prolonged diagnostic delay (≥30 days), 16 of 46
- 34.8%
- Fever associated with prolonged delay
- P = 0.009
- Fatigue associated with prolonged delay
- P = 0.011
Observational data: associations, not effects.
Further findings
Age at diagnosis and delay (cPAN subgroup)
- Significant positive correlation of age at diagnosis with delay in cPAN
Original publication
Clinical and laboratory predictors of diagnostic delay in childhood Takayasu arteritis and PAN: a retrospective cohort study. Rheumatology (Oxford). Published 9 December 2025. doi:10.
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