Childhood-onset versus adult-onset Takayasu arteritis: A study of 239 patients from China
Authors' conclusion
cTAK patients had more severe disease and inflammation. Coronary and renal artery involvement was more common among cTAK patients, whereas supra-aortic artery involvement was more common in aTAK patients increasing their risk of cerebral infarction. Biologics were used more frequently in cTAK patients.
Study context
- Population
- Chinese patients with TAK from the paediatric and adult rheumatology departments of two tertiary care centres
- Participants
- 239 patients
- Exposure
- Childhood-onset TAK vs adult-onset TAK
- cTAKn = 85
- aTAKn = 154reference
- Outcome
- Clinical features, disease activity, vascular involvement and management
Methodological detailstwo tertiary care centres, paediatric and adult rheumatology departments
- Two tertiary care centres
- Paediatric and adult rheumatology departments
Main finding
As reported in the abstract
- Fever, hypertension, arrhythmia and HF more frequent in cTAK
Observational data: associations, not effects.
Further findings
Treatment with biological agents
P < 0.001
| Outcome | cTAK | aTAK | P value |
|---|---|---|---|
| Female/male ratio | 2.3:1 | 10.8:1 | P < 0.001 |
| Indian Takayasu Clinical Activity ScoreMedian | 5 | 3 | P = 0.004 |
- Supra-aortic artery involvement
- P < 0.05
- Coronary and renal artery involvement
- P < 0.05
Supra-aortic artery involvement
- Significantly higher prevalence in aTAK than cTAK
Coronary and renal artery involvement
- Significantly lower rate in aTAK than cTAK
Original publication
Childhood-onset versus adult-onset Takayasu arteritis: A study of 239 patients from China. Joint Bone Spine. Published 29 October 2024. doi:10.
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