Pediatrics hyperuricemia in clinical practice: A retrospective analysis in 1753 children and adolescents with hyperuricemia
Authors' conclusion
Asymptomatic hyperuricemia is a relatively common biochemical finding in pediatric clinical practice.
Study context
- Population
- Children and adolescents <19 years with S-UA measured, 2013–202333,900 samples
- Participants
- 13,890 children
- Outcome
- Prevalence of hyperuricemia (S-UA>370μmol/L in girls, >420μmol/L in boys)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Hyperuricemia
Hyperuricemia
1753 patients
12.6%
Mild hyperuricemia in boys<13 years
303
Observational data: associations, not effects.
Further findings
Associated conditions
- Obesity (BMI>95th percentile), girls
- 27.8%
- Obesity (BMI>95th percentile), boys
- 26.3%
- CKD, boys
- 18.6%
- CKD, girls
- 11.4%
- Connective tissue disorders
- 10.6%
- Inherited metabolic disorders
- 10.7%
- Transitory hyperuricemia with acute gastroenteritis, girls
- 19.1%
- Transitory hyperuricemia with acute gastroenteritis, boys
- 10.1%
ULT in severe hyperuricemia
- Treated with ULT
- 73
- S-UA before ULT (μmol/L)
- 556±107
- Fraction excretion of UA
- 3.27±1.98%
- S-UA after allopurinol 50-100mg daily (μmol/L)
- 350±80
- Dose increased to 200-300mg in extremely obese adolescents (weight 98-149kg)
Original publication
Pediatrics hyperuricemia in clinical practice: A retrospective analysis in 1753 children and adolescents with hyperuricemia. Joint Bone Spine. Published 28 October 2024. doi:10.
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