Assessing Methotrexate Adherence in Juvenile Idiopathic Arthritis Using Electronic Health Record–Linked Pharmacy Dispensing Data
Main finding · Change in active joint count from baseline to 12-month follow-up (multivariable analysis)Result — go to the resultDifference −0.38 joints 95% CI −0.74 to −0.01Authors' conclusion
We identified demographic and area-level determinants of adherence, along with small but statistically significant differences in JIA disease activity measures by adherence status.
Study context
- Population
- Incident methotrexate (MTX) recipients with juvenile idiopathic arthritis (JIA) treated between January 2016 and September 2023 for ≥12 months, single centre
- Participants
- 224 recipients
- Exposure
- MTX-adherent vs nonadherent
- Nonadherentn = 81reference
- Outcome
- MTX adherence (MPR) and its association with change in active joint count
- Follow-up
- 12 months
Methodological detailssingle-centre, electronic health record (EHR)-linked pharmacy dispensing data, multivariable linear regression
- Single-centre
- EHR-linked pharmacy dispensing data
- Multivariable linear regression
Main finding
As reported in the abstract
Change in active joint count from baseline to 12-month follow-up (multivariable analysis)
Difference
−0.38 joints
95% CI −0.74 to −0.01
Events by group
Nonadherent
36.2%
81
Adherentvs Nonadherent
difference −0.38 joints (95% CI −0.74 to −0.01)
Observational data: associations, not effects.
Further findings
Change in active joint count, polyarticular course · 12 months
- Change in active joint count in patients with polyarticular course
- −1.18 (95% CI −2.23 to −0.13)
Characteristics associated with nonadherence (bivariate analysis)
- Younger age, Black race and areas with lower child opportunity index more likely nonadherent
Original publication
Assessing Methotrexate Adherence in Juvenile Idiopathic Arthritis Using Electronic Health Record–Linked Pharmacy Dispensing Data. Arthritis Care Res (Hoboken). Published 25 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →