Effects of Biologics on Temporomandibular Joint Inflammation in Juvenile Idiopathic Arthritis
Authors' conclusion
This is the first prospective, observational study with evidence to support that the orofacial signs, symptoms, and MRI-derived inflammation score in TMJ arthritis can be reduced by treatment with TNFi.
Study context
- Population
- Patients with juvenile idiopathic arthritis (JIA) and magnetic resonance imaging (MRI)-verified temporomandibular joint (TMJ) arthritis treated with TNFi (with or without methotrexate (MTX) or leflunomide (LEF)), single centre, September 2018–April 202389% female
- Participants
- 18 patients
- Exposure
- Baseline vs 24 months after initiation of TNFi
- Outcome
- MRI-based TMJ inflammation score
- Follow-up
- 24 months
Methodological detailsobservational, single-centre, consecutive patients
- Observational
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
MRI inflammation score
Baseline
2
median · IQR 1–3
24 months
1
median · IQR 0–2
P = 0.009
Observational data: associations, not effects.
Further findings
MRI deformity score · 24 months
- Deformity score improved or remained stable in 17 of 36 TMJs
- 47%
- No significant increase in the median deformity score
Orofacial signs and symptoms · during observation period
- TMJ movement pain significantly improved
- P = 0.01
- Morning stiffness significantly improved
- P = 0.004
- Opening capacity significantly improved
- P = 0.03
- Maximal incisal opening significantly improved
- P = 0.006
Original publication
Effects of Biologics on Temporomandibular Joint Inflammation in Juvenile Idiopathic Arthritis. J Rheumatol. Published 1 December 2024. doi:10.
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