Examination of antinuclear antibody staining patterns and titers in patients with childhood-onset systemic lupus erythematosus
Authors' conclusion
Our study showed that AC-4/5 and AC-1 patterns of ANA are frequently detected in many clinical and serological features of childhood-onset SLE patients.
Study context
- Population
- Patients with childhood-onset systemic lupus erythematosus (SLE)F/M = 3/1
- Participants
- 223 patients
- Outcome
- Frequency of ANA staining patterns in disease-related features
Methodological detailsMedian age at diagnosis 14.3 (11.9-16.1) years
- Median age at diagnosis 14.3 (11.9-16.1) years
Main finding
As reported in the abstract
ANA staining patterns
AC-4/5 (fine or large speckled): most common nuclear antinuclear antibodies (ANA) pattern
75.8%
AC-19 (dense fine speckled): most frequent cytoplasmic ANA pattern
13.1%
Observational data: associations, not effects.
Further findings
ANA patterns by clinical features
- AC-4/5 notably seen in fever, acute and chronic cutaneous lupus, arthritis, serositis, hematologic, renal, neuropsychiatric, gastrointestinal and cardiopulmonary involvement
- all p < .001
- AC-1 (homogeneous) significantly detected in oral/nasal ulcers and non-scarring alopecia
- both p < .001
ANA patterns by laboratory features
- AC-4/5 predominant in autoimmune hemolytic anemia, leukopenia, thrombocytopenia, elevated ESR and CRP, hypocomplementemia, direct Coombs, anti-Sm, anti-SSA and SS-B, anti-RNP, anti-histone, anti-ribosomal P, LA, aCL IgM/IgG and anti-β2-glycoprotein IgM/IgG positivities
- all p < .001
- AC-1 detected in anti-dsDNA and anti-histone positivity
- both p < .001
Original publication
Examination of antinuclear antibody staining patterns and titers in patients with childhood-onset systemic lupus erythematosus. Lupus. Published 27 November 2024. doi:10.
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