Serological biomarkers of juvenile idiopathic arthritis (JIA)-associated uveitis: ANA titers, ANA Anti-Cell (AC-30) staining pattern and prefoldin 5 antibodies
Authors' conclusion
High ANA titers, the AC-30 ANA indirect immunofluorescence (IIF) pattern, and younger age at JIA onset are significantly associated with uveitis in JIA. Anti-PFDN5 antibodies show potential as a novel biomarker for JIA-associated uveitis.
Study context
- Population
- Newly diagnosed JIA patients from a German inception cohort (ICON)
- Participants
- 52 vs 141
- Exposure
- JIA with uveitis vs JIA without uveitis
- Uveitisn = 52
- No uveitisn = 141reference
- Outcome
- Serum biomarkers associated with development of uveitis
Methodological detailsbiomarker analysis of a convenience sample from a prospective inception cohort, convenience sample enriched for uveitis cases, prospectively followed inception cohort (ICON), baseline biobanked serum, multi-analyte array technologies
- Biomarker analysis of a convenience sample from a prospective inception cohort
- Convenience sample enriched for uveitis cases
- Prospectively followed inception cohort (ICON)
- Baseline biobanked serum
- Multi-analyte array technologies
Main finding
As reported in the abstract
Serum autoantibodies associated with uveitis · baseline
ANA titer, median [IQR]
960 [240-5120] vs. 160 [0-640]
P < 0.001
Uveitis
AC-30 indirect immunofluorescence (IIF) staining pattern
63.5% vs. 23.4%
P < 0.001
Uveitis
PFDN5 antibody titer, mean ± SD
486.39 ± 495.85 vs. 321.85 ± 330.36
P = 0.010
Uveitis
Observational data: associations, not effects.
Further findings
- Uveitis-related complications at first uveitis documentation
- 26%
Original publication
Serological biomarkers of JIA-associated uveitis: ANA titers, ANA AC-30 staining pattern and prefoldin 5 antibodies. Arthritis Res Ther. Published 26 May 2026. doi:10.
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