Different patterns of longitudinal changes in antinuclear antibodies titers in children with systemic lupus erythematosus and Sjögren's syndrome
Authors' conclusion
At 2 years of follow-up, all pSLE patients had a lower ANA titer and 26% became negative; however, all pSS patients remained both ANA and ENA positive.
Study context
- Population
- Children with pediatric systemic lupus erythematosus (pSLE) and pediatric Sjögren's syndrome (pSS); autoantibody testing every 3–4 months for 2 years from disease onset
- Participants
- 21 vs 22
- Exposure
- pSLE vs pSS
- pSLEn = 21
- pSSn = 22
- Outcome
- Trend of autoantibody titers
- Follow-up
- 2 years
Methodological detailslongitudinal, 2-year follow-up
- Longitudinal
- 2-year follow-up
Main finding
As reported in the abstract
ANA status at 2 years (pSLE)
Still ANA positive at 2 years
11
73%
Became ANA negative
4
26%
pSS: all remained ANA positive at 2 years, with significantly lower titers
100%
Observational data: associations, not effects.
Further findings
ANA pattern at diagnosis in pSLE
- Homogeneous pattern
- 12 (80%)
- Speckled pattern (remained ANA positive, same pattern)
- 3 (20%)
- Homogeneous converted to speckled
- 2
- Homogeneous became ANA negative
- 4
Interferon score, ANA negative vs ANA positive pSLE
- ANA negative pSLE patients had lower interferon score than ANA positive
Anti-dsDNA titers in pSLE
- Declined equally in the two groups
ENA in pSS
- Anti-La positive at onset
- 14 (66%)
- All ANA and anti-Ro positive at disease onset
- Anti-Ro and anti-La titers remained stable during follow-up
Original publication
Different patterns of longitudinal changes in antinuclear antibodies titers in children with systemic lupus erythematosus and Sjögren's syndrome. Lupus. Published 4 November 2024. doi:10.
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