Antibodies to histone in the pediatric population: a retrospective chart review
Authors' conclusion
The presence of anti-histone antibody was observed in a variety of diagnoses in the pediatric population. Overall, the presence of anti-histone antibodies appears to have poor diagnostic utility for any specific condition.
Study context
- Population
- Pediatric patients with positive anti-histone antibody testing41 different diagnoses
- Participants
- 139 patients
- Exposure
- Weak vs moderate vs strong anti-histone antibody titers
- Weak titern = 62reference
- Outcome
- Diagnoses in children with positive anti-histone antibodies
Methodological detailsconsecutive three year period
- Consecutive three year period
Main finding
As reported in the abstract
- Hypermobility arthralgia (most common diagnosis)
- 22
- Juvenile idiopathic arthritis (JIA) (nonsystemic) (most frequent rheumatologic diagnosis)
- 19
- Systemic lupus erythematosus (SLE)
- 13
- DILE
- 2
- Other autoantibody production
- 18
- SLE or DILE among those with other autoantibody production
- 11
Observational data: associations, not effects.
Further findings
- SLE by anti-histone antibody titer — Weak titer
- 1 events
- SLE by anti-histone antibody titer — Strong titers: SLE incidence ten times higher than weak titer
- 10
SLE by anti-histone antibody titer
- Strong titers: >50% incidence of underlying rheumatologic disease
- Statistically significant difference in SLE frequency between weak and moderate titers and between weak and strong titers
Original publication
Antibodies to histone in the pediatric population: a retrospective chart review. Pediatr Rheumatol Online J. Published 25 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →