Elevated nil values in TB-IGRA: a potential diagnostic clue for pediatric histiocytic necrotizing lymphadenitis
Authors' conclusion
The routinely available yet often overlooked Nil value from the TB-IGRA is significantly elevated in pediatric HNL and demonstrates favorable diagnostic accuracy.
Study context
- Population
- Children with Histiocytic Necrotizing Lymphadenitis (HNL) who had TB-IGRA testing, Women and Children's Medical Center, Guangzhou Medical University, January 2019–December 2024
- Participants
- 48 HNL patients
- Comparison
- TB-Nil values in HNL vs systemic juvenile idiopathic arthritis (sJIA), Kawasaki disease (KD) and bacterial lymphadenitis
- HNLn = 48
- Outcome
- Diagnostic performance of TB-IGRA Nil value (TB-Nil) for HNL
Methodological detailssingle-centre, ROC curve analysis
- Single-centre
- ROC curve analysis
Performance
As reported in the abstract
| Test or model | Value | AUC | Optimal cutoff | Sensitivity | Specificity |
|---|---|---|---|---|---|
| HNL | median 0.82 (IQR 0.36–1.18) IU/mL | 0.8781 (95%CI: 0.8138-0.9424) | 0.19 IU/mL | 78.38% | 91.67% |
| sJIA | median 0.07 IU/mL | ||||
| KD | median 0.09 IU/mL | ||||
| Bacterial lymphadenitis (BL) | median 0.09 IU/mL |
Value
HNLmedian 0.82 (IQR 0.36–1.18) IU/mL
sJIAmedian 0.07 IU/mL
KDmedian 0.09 IU/mL
Bacterial lymphadenitis (BL)median 0.09 IU/mL
AUC
HNL0.8781 (95%CI: 0.8138-0.9424)
sJIA— not stated in the abstract
KD— not stated in the abstract
Bacterial lymphadenitis (BL)— not stated in the abstract
Optimal cutoff
HNL0.19 IU/mL
sJIA— not stated in the abstract
KD— not stated in the abstract
Bacterial lymphadenitis (BL)— not stated in the abstract
Sensitivity
HNL78.38%
sJIA— not stated in the abstract
KD— not stated in the abstract
Bacterial lymphadenitis (BL)— not stated in the abstract
Specificity
HNL91.67%
sJIA— not stated in the abstract
KD— not stated in the abstract
Bacterial lymphadenitis (BL)— not stated in the abstract
- HNL vs sJIA: P < 0.0001
- HNL vs KD: P < 0.0001
- HNL vs BL: P < 0.0001
Original publication
Elevated nil values in TB-IGRA: a potential diagnostic clue for pediatric histiocytic necrotizing lymphadenitis. Pediatr Rheumatol Online J. Published 10 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →