Clinical features and recurrence predictors of histiocytic necrotizing lymphadenitis in Chinese children
Authors' conclusion
Our study demonstrates that fever and cervical lymphadenopathy are the most frequent clinical manifestations of HNL in Chinese children, which often coexist with aseptic meningitis.
Study context
- Population
- Chinese children with histopathologically confirmed histiocytic necrotizing lymphadenitis (HNL), single centre in China, January 2018 to May 2023121 males and 60 females
- Participants
- 181 children
- Outcome
- Clinical features and predictors of HNL recurrence
Methodological detailssingle-centre, logistic regression
- Single-centre
- Logistic regression
Main finding
As reported in the abstract
- Fever
- 98.9%
- Cervical lymphadenopathy
- 98.3%
- Aseptic meningitis (most frequent complication)
- 38.5%
- Haemophagocytic lymphohistiocytosis
- 1.7%
- Autoimmune disease
- 1.2%
- Recurrence
- 12.7%
- ESR > 30 mm/h as predictor of recurrence, OR
- 6.107
Observational data: associations, not effects.
Original publication
Clinical features and recurrence predictors of histiocytic necrotizing lymphadenitis in Chinese children. Pediatr Rheumatol Online J. Published 11 June 2024. doi:10.
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