Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score
Authors' conclusion
The sJADAS cutoffs revealed good metrologic properties in both definition and validation cohorts and are therefore suitable for use in clinical trials and routine practice.
Study context
- Population
- Children with sJIA enrolled at 30 pediatric rheumatology centers in 11 countries
- Participants
- 400 children30 centres11 countries
- Outcome
- sJADAS10 cutoffs distinguishing ID, MDA, moderate disease activity and high disease activity
Methodological detailsdevelopment and validation of disease activity cutoffs, multicentre, international, definition and validation cohorts (60%/40%), subjective physician rating as external criterion, Six methods to identify cutoffs: mapping, percentiles of cumulative score distribution, Youden index, 90% specificity, maximum agreement, ROC curve analysis
- Development and validation of disease activity cutoffs
- Multicentre
- International
- Definition and validation cohorts (60%/40%)
- Subjective physician rating as external criterion
- Six methods to identify cutoffs: mapping, percentiles of cumulative score distribution, Youden index, 90% specificity, maximum agreement, ROC curve analysis
Performance
As reported in the abstract
sJADAS10 cutoffs
Cutoff separating inactive disease (ID) from minimal disease activity (MDA)
≤2.9
Cutoff separating MDA from moderate disease activity
≤10
Cutoff separating moderate from high disease activity
>20.6
Further findings
Discriminative ability of the cutoffs
- Cutoffs discriminated strongly among levels of pain, between patients with and without morning stiffness, and by parent judgement of disease status (remission vs persistent activity or flare) and satisfaction with illness outcome
Original publication
Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score. Arthritis Rheumatol. Published 11 June 2024. doi:10.
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