Characterization of juvenile idiopathic arthritis (JIA) subtypes, clinical features, treatment patterns, and early outcomes in Palestinian children: a retrospective cohort study
Authors' conclusion
Systemic and PRF- JIA were linked to higher inflammatory activity and poorer short-term outcomes.
Study context
- Population
- Children diagnosed with JIA between January 2019 and August 2025, pediatric rheumatology centers in Hebron, Palestine
- Participants
- 171 children
- Exposure
- Oligoarticular vs non-oligoarticular JIA
- Outcome
- Remission or relapse based on Wallace criteria
- Follow-up
- Six months
Methodological detailsmultivariable logistic regression
- Multivariable logistic regression
Main finding
As reported in the abstract
Remission or relapse (Wallace criteria)
Achieved remission
53.8%
Relapsed
46.2%
Observational data: associations, not effects.
Further findings
Subtype distribution
- Persistent oligoarticular JIA
- 38.0%
- Polyarticular RF-negative (PRF-)
- 22.8%
- Enthesitis-related arthritis (ERA)
- 14.6%
Clinical features
- Knee arthritis (most frequent joint involvement)
- 63.7%
- Systemic JIA: younger age at onset and higher inflammatory burden
- Extra-articular manifestations (oral ulcers, rash, uveitis) differed across subtypes
Treatment use
- NSAIDs
- 62.0%
- MTX
- 79.5%
- Biologics
- 22.2%
Factors associated with oligoarticular subtype (multivariable)
- Younger age, knee involvement, lower ESR and six-month remission independently associated with oligoarticular subtype
Original publication
Characterization of JIA subtypes, clinical features, treatment patterns, and early outcomes in Palestinian children: a retrospective cohort study. Pediatr Rheumatol Online J. Published 27 February 2026. doi:10.
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