Juvenile dermatomyositis in Oman: clinical patterns and disease trajectory from a National cohort
Authors' conclusion
This study provides comprehensive characterization of pediatric JDM in Oman. The findings highlight regional variations in disease presentation, autoantibody profiles, and treatment responses
Study context
- Population
- Children with juvenile dermatomyositis (JDM) managed by pediatric rheumatologists in tertiary centres in Omanfemale:male 1:1
- Participants
- 30 children
- Outcome
- Clinical features, disease course and outcomes
Methodological detailsnational cohort, tertiary centres
- National cohort
- Tertiary centres
Main finding
As reported in the abstract
- Median age at onset, years (range 2-13)
- 6.78
- Median diagnostic delay, months (range 1-23)
- 8.4
- Median follow-up, years (range 1 month-16 years)
- 4
- Heliotrope rash, n (%)
- 25 (83%)
- Gottron's papules, n (%)
- 23 (77%)
- Proximal muscle weakness, n (%)
- 28 (93%)
- Elevated muscle enzymes, n (%)
- 23 (77%)
- MRI consistent with myositis
- 70% (n = 19/27)
- Muscle biopsy confirmed JDM, n (%)
- 9 (30%)
- Myositis-specific antibodies among 25 tested: NXP2 / anti-TIF1 / anti-Mi-2 / MDA5, n
- 3 / 2 / 1 / 1
- Corticosteroids
- universally administered
- Methotrexate, n (%)
- 25 (83%)
- IVIG, n (%)
- 15 (50%)
- Calcinosis, n (%)
- 8 (27%)
- Clinical remission at last follow-up, n (%)
- 18 (60%)
- Polyphasic or chronic course
- 50% (n = 15)
Observational data: associations, not effects.
Further findings
Disease outcome at last follow-up
- Clinical remission
- 18 (60%)
- Polyphasic or chronic disease course
- 15 (50%)
- Died of disease-related complications
- 2
- Median follow-up 4 years (absolute range: 1 month-16 years)
Calcinosis
- Calcinosis
- 8 (27%)
- Managed with pamidronate
- 3
- Managed with diltiazem
- 2
- Managed with infliximab
- 1
Treatment
- Corticosteroids
- universally administered
- MTX
- 25 (83%)
- IVIG
- 15 (50%)
Original publication
Juvenile dermatomyositis in Oman: clinical patterns and disease trajectory from a National cohort. Pediatr Rheumatol Online J. Published 17 July 2025. doi:10.
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