Nailfold video capillaroscopy as a non-invasive biomarker in juvenile dermatomyositis: A longitudinal analysis of microvascular changes and clinical relevance over one year
Authors' conclusion
Nailfold video capillaroscopy provides valuable insights into microvascular alterations in JDM and correlates with clinical disease activity, particularly cutaneous involvement.
Study context
- Population
- Children with juvenile dermatomyositis (JDM) at two tertiary pediatric rheumatology clinics
- Participants
- 20 children
- Exposure
- JDM patients vs controls
- JDMn = 20
- Outcome
- Longitudinal changes in NVC findings and their associations with clinical disease activity and serologic markers
- Follow-up
- One year
Methodological detailslongitudinal, two tertiary pediatric rheumatology clinics
- Longitudinal
- Two tertiary pediatric rheumatology clinics
Main finding
As reported in the abstract
NVC abnormalities, JDM vs controls
- Reduced capillary density and increased prevalence of dilated, giant, bushy, bizarre and hemorrhagic capillaries in JDM vs controls
- all p < 0.001
- Capillary density moderate inverse correlation with Skin DAS
- r = −0.429
- Capillary density and apical loop diameter significant predictors of skin disease activity over time
- p < 0.05
Observational data: associations, not effects.
Further findings
Nailfold video capillaroscopy (NVC) by myositis-specific antibody subgroup
- Anti-TIF1-γ: lowest capillary density and greatest apical loop diameter
Original publication
Nailfold video capillaroscopy as a non-invasive biomarker in juvenile dermatomyositis: A longitudinal analysis of microvascular changes and clinical relevance over one year. Semin Arthritis Rheum. Published 19 February 2026. doi:10.
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