Microvascular changes on nailfold capillaroscopy in acute stage of Kawasaki disease: a new diagnostic paradigm for an enigmatic condition
Authors' conclusion
Results show that patients with KD have significant nailfold capillary changes in the acute phase.
Study context
- Population
- Children diagnosed with kawasaki disease (KD) based on American Heart Association guidelines 2017 (17 boys; median age 3 years)32 children with KD
- Participants
- 32 / 17 / 32
- Exposure
- Nailfold capillaroscopy in acute-phase KD vs subacute/convalescent phase and controls
- Acute phasen = 32
- Subacute/convalescent phasen = 17
- Controlsn = 32reference
- Outcome
- Nailfold capillary changes (Optilia video capillaroscopy) in acute phase of KD
- Follow-up
- Acute phase (prior to IVIG)
Methodological detailscontrolled (32 controls)
- Controlled (32 controls)
Main finding
As reported in the abstract
Reduced capillary density
Acute phase vs Subacute/convalescent phase: P < 0.001 · Acute phase vs Controls: P = 0.03
Observational data: associations, not effects.
Further findings
Other nailfold capillaroscopy (NFC) findings in acute phase
- Dilated capillaries (n = 3)
- 9.3%
- Ramifications (n = 3)
- 9.3%
- Capillary haemorrhages (n = 2)
- 6.2%
Correlation between coronary artery involvement and mean capillary density
- No correlation
- P = 0.870
Original publication
Microvascular changes on nailfold capillaroscopy in acute stage of Kawasaki disease: a new diagnostic paradigm for an enigmatic condition. Rheumatology (Oxford). Published 18 May 2023. doi:10.
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