HLA–DRB1*15 and Eosinophilia Are Common Among Patients With Systemic Juvenile Idiopathic Arthritis
Authors' conclusion
Carriage of DRB1*15 was more common in this cohort of patients with systemic JIA than in the general population. Eosinophilia and systemic JIA-LD were more common among patients with severe systemic JIA complicated by macrophage activation syndrome.
Study context
- Population
- Subjects with sJIA followed for at least 6 months between 1996 and 2022 at one center23 with HLA typing
- Participants
- 86 subjects
- Exposure
- Patients with vs without eosinophilia; with vs without DRB1*15; with vs without sJIA-LD
- sJIA-LDn = 7
- Outcome
- Carriage of HLA-DRB1*15 and eosinophilia, and their association with adverse drug reactions and sJIA-LD
Methodological detailsretrospective chart review, single-centre
- Retrospective chart review
- Single-centre
Main finding
As reported in the abstract
Carriage of HLA-DRB1*15 among patients with HLA typing
Carried DRB1*15, of 23 patients with HLA typing
74%
Carried DRB1*15, patients without systemic JIA-LD
63%
Subjects with systemic JIA-LD, all of whom carried DRB1*15
7
Observational data: associations, not effects.
Further findings
Exposure to IL-1 and IL-6 blockers
- Exposure to IL-1 and IL-6 blockers
- 95%
Death
- Deaths, unrelated to active sJIA disease
- 1
Original publication
HLA–DRB1*15 and Eosinophilia Are Common Among Patients With Systemic Juvenile Idiopathic Arthritis. Arthritis Care Res (Hoboken). Published 15 May 2023. doi:10.
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