Autoinflammatory & rare systemic diseases
Examination of HLA-DRB1*15–linked Candidate Antigens in Still Disease With and Without Lung Disease and Drug-Associated Immune Reactions
Authors' conclusion
The absence of anti-A. fumigatus IgE antibodies and detectable herpesvirus nucleic acids in subjects with Still-LD and DAIR does not support a mechanistic association with hypersensitivity to A. fumigatus or with HHV reactivation.
Study context
- Population
- Pediatric and adult subjects from the NIH Still disease cohort (sJIA and AOSD), with and without lung disease and drug-associated immune reactions
- Participants
- 54 participants
- Comparison
- Lung disease (LD) and drug-associated immune reactions (DAIR) vs DAIR alone
- LD and DAIRn = 11
- DAIR alonen = 8
- Outcome
- Candidate antigens: anti-A. fumigatus IgE and herpesvirus (CMV, EBV, HHV-6) testing
Methodological detailscohort-based, chart review
- Cohort-based
- Chart review
Main finding
As reported in the abstract
Tested for cytomegalovirus (CMV), Epstein-Barr virus (EBV) and HHV-6
49
EBV positive, neither with Still-LD or DAIR
2
Original publication
Examination of HLA-DRB1*15–linked Candidate Antigens in Still Disease With and Without Lung Disease and Drug-Associated Immune Reactions. J Rheumatol. Published 15 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →