Involvement of the systemic microcirculation in pediatric uveitis
Authors' conclusion
Children with uveitis without systemic disease can present with changes in systemic microcirculation. These changes vary amongst the subtypes of uveitis.
Study context
- Population
- Children with noninfectious uveitis (mean age 13.7 years; 56% female; 46% anterior, 18% intermediate, 36% panuveitis; mean disease duration 4.7 years) and healthy pediatric controls
- Participants
- 119 vs 25
- Comparison
- Children with noninfectious uveitis vs healthy pediatric controls
- Pediatric uveitisn = 119
- Healthy controlsn = 25reference
- Outcome
- NFC parameters: capillary density, dilated capillaries (apex > 20 µm), avascular area, microhemorrhages, capillary morphology
Methodological detailsregression analysis adjusted for age and sex
- Regression analysis adjusted for age and sex
Main finding
As reported in the abstract
NFC parameters, cases vs controls
- Significantly higher number of dilated capillaries/mm in uveitis cases vs controls
- Higher prevalence of ramified capillaries in uveitis cases vs controls
- Adjusted for age and sex
Observational data: associations, not effects.
Further findings
Nailfold capillaroscopy (NFC) parameters by uveitis subtype vs controls
- Intermediate uveitis: significantly higher number of dilated capillaries
- Anterior uveitis: lower capillary density and higher prevalence of ramified capillaries
Original publication
Involvement of the systemic microcirculation in pediatric uveitis. Pediatr Rheumatol Online J. Published 2 October 2023. doi:10.
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