Assay for interferon gamma release as a novel marker in pediatric patients with systemic lupus erythematosus
Authors' conclusion
The detection of IFN-γ release levels by the TB-IGRA may be useful to assess SLE disease activity in pediatric patients with active SLE.
Study context
- Population
- Children who underwent TB-IGRA testing, Department of Allergy and Rheumatology, Guangzhou Women and Children's Medical Center, 2018–202047 systemic lupus erythematosus (SLE) patients
- Participants
- 776 children
- Exposure
- Tuberculosis (TB) Ag-NL levels in SLE vs juvenile dermatomyositis (JDM), juvenile idiopathic arthritis (JIA) and healthy controls; active vs inactive SLE
- SLEn = 47
- Outcome
- Association between TB Ag-NL (IGRA IFN-γ release) and SLE disease activity
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
TB Ag-NL, active vs inactive SLE
- TB Ag-NL significantly higher in active than inactive SLE
- p = 0.0002
Observational data: associations, not effects.
Further findings
TB Ag-NL by diagnosis — SLE vs JDM
P = 0.036
| Outcome | P value |
|---|---|
| TB Ag-NL by diagnosisSLE vs JIA | P = 0.001 |
| TB Ag-NL by diagnosisSLE vs HC | P = 0.0003 |
Original publication
Assay for interferon gamma release as a novel marker in pediatric patients with systemic lupus erythematosus. Pediatr Rheumatol Online J. Published 1 August 2024. doi:10.
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