Peripheral blood regulatory T cells and disease activity, quality of life, and outcomes in children with juvenile idiopathic arthritis
Authors' conclusion
Higher baseline Treg levels in the peripheral blood of children with JIA may be associated with reduced disease activity and better quality of life, though were not informative on the inflammatory progression on the follow-up.
Study context
- Population
- Consecutive children with juvenile idiopathic arthritis (JIA) (ILAR criteria); median age 11 years, 63.2% girls
- Participants
- 87 children
- Outcome
- Association of peripheral blood Treg levels with disease activity, quality of life, treatment adjustment and hospitalisation
Methodological detailstwo-phase (cross-sectional and prospective), consecutive children, Spearman's correlation and Mann-Whitney U test, Cox proportional regression
- Two-phase (cross-sectional and prospective)
- Consecutive children
- Spearman's correlation and Mann-Whitney U test
- Cox proportional regression
Main finding
As reported in the abstract
Peripheral blood Tregs and outcomes
- Tregs not associated with most variables of interest
- Higher Tregs associated with lower erythrocyte sedimentation rate (ESR) and better subjective disease status and course
- Higher IL-10 and TGF-β associated with lower ESR, less pain and better subjective disease status
- No association between Tregs and treatment adjustments or hospitalisation during follow-up
Observational data: associations, not effects.
Original publication
Peripheral blood regulatory T cells and disease activity, quality of life, and outcomes in children with juvenile idiopathic arthritis. Pediatr Rheumatol Online J. Published 1 August 2024. doi:10.
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