Psoriatic arthritis spectrum in children: a multicentre observational study
Authors' conclusion
Our study showed three clinical clusters with diverse demographic and clinical characteristics, indicating JPsA heterogeneity.
Study context
- Population
- Children with International League of Associations for Rheumatology (ILAR)-defined juvenile psoriatic arthritis (JPsA)
- Participants
- 73 children
- Exposure
- Cluster 1 vs Cluster 2 vs Cluster 3
- Outcome
- Characteristics of children with ILAR-defined JPsA and whether more sensitive and specific criteria for defining JPsA can be identified
Methodological detailsobservational, multicentre, unsupervised principal component analysis
- Observational
- Multicentre
- Unsupervised principal component analysis
Main finding
As reported in the abstract
Clinical clusters (ILAR and CASPAR clinical criteria)
Three clinical clusters found
3
Observational data: associations, not effects.
Further findings
Including patients with undifferentiated arthritis
- Significance for all parameters unchanged, except MTX treatment, significantly more common in Cluster 2
- P = 0.02
- Tenosynovitis more common in Cluster 2
- P = 0.05
Combining ILAR, CASPAR and Vancouver criteria
- Patients remaining undifferentiated
- 2
Original publication
Psoriatic arthritis spectrum in children: a multicentre observational study. Clin Exp Rheumatol. Published 5 May 2026. doi:10.
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