Disease characteristics of HLA-B27 positive and negative finnish patients with juvenile idiopathic arthritis - results of the 18-year cohort follow-up study
Authors' conclusion
The use of biological medication was more common in HLA-B27 positive patients with JIA. At the 18-year follow-up, more antigen positive patients had active disease compared HLA-B27 negative patients.
Study context
- Population
- Newly diagnosed Finnish patients with juvenile idiopathic arthritis (JIA) (International League of Associations for Rheumatology (ILAR) criteria), enrolled 1997–2000, Southern FinlandHLA-B27 available for 151
- Participants
- 159 participants
- Exposure
- HLA-B27 positive vs HLA-B27 negative JIA
- Outcome
- Disease characteristics of HLA-B27 positive and negative patients
- Follow-up
- 18-year follow-up
Methodological detailsconsecutive cases, long-term follow-up, defined area of Southern Finland, Mean follow-up 17.5 years
- Consecutive cases
- Long-term follow-up
- Defined area of Southern Finland
- Mean follow-up 17.5 years
Main finding
As reported in the abstract
Disease characteristics
HLA-B27 positive
25%
Observational data: associations, not effects.
Further findings
Chronic uveitis
Temporomandibular (TMJ) involvement
Biological medication at some point during follow-up
P = 0.003
| Outcome | HLA-B27 POSITIVE | HLA-B27 NEGATIVE | P value |
|---|---|---|---|
| Cervical spine involvement | 0 events | 11% | P = 0.022 |
| Not in remission (HLA-B27 antigen positive vs antigen negative) · last follow-up | — withheld: not confirmed against the abstract | 18% | P = 0.017 |
— withheld: the automatic checks could not confirm the value against the abstract
- Not in remission (HLA-B27 antigen positive vs antigen negative): antigen positive = HLA-B27 positive; antigen negative = HLA-B27 negative
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Disease characteristics of HLA-B27 positive and negative finnish patients with juvenile idiopathic arthritis - results of the 18-year cohort follow-up study. Pediatr Rheumatol Online J. Published 1 September 2023. doi:10.
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