Children with extended oligoarticular and polyarticular juvenile idiopathic arthritis have alterations in B and T follicular cell subsets in peripheral blood and a cytokine profile sustaining B cell activation
Authors' conclusion
Our results suggest a potential role and/or activation profile of B and Th17-like Tfh cells in the pathogenesis of extended oligo JIA and poly JIA, but not persistent oligo JIA.
Study context
- Population
- Children and adults with JIA and age-matched healthy individuals105 JIA patients
- Exposure
- Extended oligo JIA and poly JIA vs healthy controls, persistent oligo JIA and adult JIA
- Healthy controlsn = 50reference
- Outcome
- Frequency and phenotype of B, Tfh and Tfr cells in peripheral blood and circulating cytokine environment
Methodological detailsage-matched healthy controls, flow cytometry, multiplex bead-based immunoassay and/or ELISA
- Age-matched healthy controls
- Flow cytometry
- Multiplex bead-based immunoassay and/or ELISA
Main finding
As reported in the abstract
B, Tfh and Tfr cell subsets and serum cytokines
- Frequency of B, T follicular helper (Tfh) and T follicular regulatory (Tfr) cells similar between JIA patients and controls
- Extended oligo JIA and poly JIA, but not persistent oligo JIA: significantly lower frequencies of plasmablasts and regulatory T cells and higher levels of Th17-like Tfh cells vs controls
- APRIL, BAFF, IL-6 and IL-17A serum levels significantly higher in paediatric extended oligo JIA and poly JIA vs controls
- These alterations not found in adult JIA vs controls
Observational data: associations, not effects.
Original publication
Children with extended oligoarticular and polyarticular juvenile idiopathic arthritis have alterations in B and T follicular cell subsets in peripheral blood and a cytokine profile sustaining B cell activation. RMD Open. Published 31 August 2023. doi:10.
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