Overlap of International League of Associations for Rheumatology and Preliminary Pediatric Rheumatology International Trials Organization Classification Criteria for Nonsystemic Juvenile Idiopathic Arthritis in an Established UK Multicentre Inception Cohort
Authors' conclusion
Under the preliminary PRINTO classification criteria for childhood arthritis, most children are not yet classified into a named category.
Study context
- Population
- Children and young people with a physician's diagnosis of juvenile idiopathic arthritis (JIA) in the Childhood Arthritis Prospective Study, a multicentre UK JIA inception cohort; systemic JIA excluded
- Participants
- 1,223 children
- Exposure
- Paediatric Rheumatology International Trials Organisation (PRINTO) vs International League of Associations for Rheumatology (ILAR) classification criteria for nonsystemic JIA
- Outcome
- Degree of overlap between ILAR and PRINTO classification categories
Methodological detailsclassification criteria comparison in a multicentre inception cohort, prospective, PRINTO criteria adapted to a UK health care setting, including limiting the number of blood biomarker tests required
- Classification criteria comparison in a multicentre inception cohort
- Prospective
- PRINTO criteria adapted to a UK health care setting, including limiting the number of blood biomarker tests required
Main finding
As reported in the abstract
- PRINTO "other JIA" (majority of patients)
- 69.5%
- Overlap between PRINTO enthesitis/spondylitis- and ILAR enthesitis-related JIA categories
- 91%
- PRINTO rheumatoid factor (RF)-positive category: ILAR RF-positive polyarthritis
- 48%
- PRINTO RF-positive category: ILAR undifferentiated JIA
- 52%
- PRINTO early-onset ANA-positive category: ILAR oligoarthritis
- 50%
- PRINTO early-onset ANA-positive category: ILAR RF-negative polyarthritis
- 24%
- PRINTO early-onset ANA-positive category: ILAR undifferentiated JIA
- 23%
- Unclassified under PRINTO (n)
- 3
- Unclassified under PRINTO, previously ILAR enthesitis-related JIA (n)
- 1
- Unclassified under PRINTO, previously ILAR undifferentiated JIA (n)
- 2
Observational data: associations, not effects.
Original publication
Overlap of International League of Associations for Rheumatology and Preliminary Pediatric Rheumatology International Trials Organization Classification Criteria for Nonsystemic Juvenile Idiopathic Arthritis in an Established UK Multicentre Inception Cohort. Arthritis Care Res (Hoboken). Published 15 March 2024. doi:10.
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