Long-term follow-up of 109 children with juvenile idiopathic oligoarthritis after first intra-articular corticosteroid injection
Authors' conclusion
Almost 40% of children with oligoarticular JIA requiring IAC did not progress to chronic disease. Younger age, ANA positivity, and HLA B27 presence were predictive factors for systemic therapy, while the number of injected joints predicted the future need for biologic therapy.
Study context
- Population
- Children with juvenile idiopathic arthritis (JIA) presenting as oligoarthritis receiving IAC as initial treatment, University Children's Hospital Ljubljana, Slovenia, January 2015 to May 202363% female
- Participants
- 109 children
- Exposure
- No therapy needed vs Only additional IAC needed vs Systemic therapy needed
- Outcome
- Long-term outcomes (later need for therapy) and prognostic factors after first IAC
Methodological detailssingle-centre, log-rank (Mantel-Cox) survival analyses
- Single-centre
- Log-rank (Mantel-Cox) survival analyses
Main finding
As reported in the abstract
Later need for therapy after first IAC · 4.3-year follow-up
- Systemic therapy, mainly methotrexate (MTX), initiated in average months post-IAC
- 7.8
- Biologic therapy initiated (proportion of patients)
- 22%
- Biologic therapy initiated in average years post-IAC
- 2.2
Observational data: associations, not effects.
Further findings
Inactive disease at last follow-up
- Inactive disease
- 88.9%
Predictors of need for systemic therapy
- ANA positivity (chi square 3.89)
- P = 0.049
- HLA-B27 presence (chi square 3.85)
- P = 0.050
Need for biologics
- Number of injected joints correlated with the need for biologics
Subgroup >8 years, ANA and HLA-B27 negative vs other patients
- Systemic therapy in subgroup
- 25.8%
- Biologic therapy in subgroup
- 9.6%
- Significantly less vs other patients (chi square 3.77)
- P = 0.050
Original publication
Long-term follow-up of 109 children with juvenile idiopathic oligoarthritis after first intra-articular corticosteroid injection. Arthritis Res Ther. Published 14 March 2024. doi:10.
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