Neutrophils extracellular traps formation may serve as a biomarker for disease activity in oligoarticular juvenile idiopathic arthritis: a pilot study
Authors' conclusion
We demonstrated a statistically significant linear correlation between cJADAS-10 and NETs formation in oligo but not in poly JIA patients.
Study context
- Population
- Children with oligoarticular and polyarticular juvenile idiopathic arthritis (JIA), at diagnosis and after intra-articular GC injection, and healthy controls7 JIA patients
- Comparison
- Oligoarticular and polyarticular JIA vs healthy controls; at diagnosis and after intra-articular GC injection
- Healthy controlsn = 6reference
- Outcome
- Neutrophil enzyme activity and PMA-activated NETs formation and their association with disease activity
- Follow-up
- At diagnosis and after intra-articular GC injection
Methodological detailspilot and feasibility study
- Pilot and feasibility study
Main finding
As reported in the abstract
NETs formation · At diagnosis
- Correlation of NETs formation with cJADAS-10 linear and significant in oligo but not in poly JIA
- P = 0.007
Original publication
Neutrophils extracellular traps formation may serve as a biomarker for disease activity in oligoarticular juvenile idiopathic arthritis: a pilot study. Arthritis Res Ther. Published 31 July 2023. doi:10.
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